RESEARCH
INHIBITORY IMMUNE RECEPTORS
We are interested in exploring inhibitory immune receptors and their crucial role in regulating immune responses. We are particularly fascinated by understanding how these receptors modulate immune cell functions, contribute to immune homeostasis, and modulate antibacterial immune responses. By investigating the intricate mechanisms underlying inhibitory immune receptor signaling, we aim to uncover novel therapeutic targets for immune-mediated diseases and advance our understanding of immune regulation.
BACTERIAL IMMUNE EVASION
Bacteria often possess multiple strategies to evade detection or killing by our innate immune cells. We investigate how bacterial pathogens exploit inhibtory receptors to modulate innate immune responses. By dissecting these sophisticated evasion mechanisms, we hope to identify vulnerabilities in bacterial pathogens and develop innovative approaches to enhance host immunity and combat infectious diseases.
STREPTOCOCCI
Streptococci bacteria can cause a diverse range of diseases in humans. A focus in our laboratory is understanding how streptococcal pathogens, including Streptococcus pyogenes (Group A Streptococcus) and Streptococcus agalactiae (Group B Streptococcus) interact with immune cells to suppress immune cell activity and cause infections.
EXTRAINTESTINAL PATHOGENIC E. COLI (EXPEC)
We are interested in understanding the evolution and virulence mechanisms of ExPEC, exploring their interactions with the host immune system, and using this knowledge to develop better therapeutics. We hope this contributes to the advancement of knowledge in this field and ultimately improves possibilities to protect at-risk individuals and/or improve outcomes for patients affected by ExPEC-related infections.
